![](/images/graphics-bg.png)
CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production
Joint Authors
Yao, Shanglong
Gui, Ping
Wu, Zhi-Lin
Lv, Jing
Gan, Zheng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
CXCL14 is a relatively novel chemokine with a wide spectrum of biological activities.
The present study was designed to investigate whether CXCL14 overexpression attenuates sepsis-associated acute kidney injury (AKI) in mice.
Sepsis model has been established by cecal ligation and puncture (CLP).
CLP induced AKI in mice as assessed by increased renal neutrophil gelatinase-associated lipocalin (NGAL) expression and serum creatinine levels.
We found that renal CXCL14 expression in the kidney was significantly decreased at 12 hours after CLP.
Correlation analysis demonstrated a negative association between renal CXCL14 expression and AKI markers including serum creatinine and renal NGAL.
Moreover, CXCL14 overexpression reduced cytokine (TNF-α, IL-6, and IL-1β) production and NGAL expression in the kidney and decreased serum creatinine levels.
In vivo and in vitro experiments found that CXCL14 overexpression inhibited M1 macrophage polarization but increased M2 polarization.
Together, these results suggest that CXCL14 overexpression attenuates sepsis-associated AKI probably through the downregulation of macrophages-derived cytokine production.
However, further studies are required to elucidate the underlying mechanism.
American Psychological Association (APA)
Lv, Jing& Wu, Zhi-Lin& Gan, Zheng& Gui, Ping& Yao, Shanglong. 2020. CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191575
Modern Language Association (MLA)
Lv, Jing…[et al.]. CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production. Mediators of Inflammation No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1191575
American Medical Association (AMA)
Lv, Jing& Wu, Zhi-Lin& Gan, Zheng& Gui, Ping& Yao, Shanglong. CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191575