Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias
Joint Authors
Fukuda, Yuh
Sasano, Hironobu
Yamashita, Masahiro
Saito, Ryoko
Yasuhira, Shinji
Yamauchi, Kohei
Maemondo, Makoto
Sugai, Tamotsu
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The types of cells most significantly linked to individual subtypes of idiopathic interstitial pneumonias (IIPs) remain unclear.
Few studies have examined CD163+ macrophages in IIPs.
Objective.
We retrospectively aimed to immunohistochemically characterize the CD163+ macrophages in IIPs.
Methods.
Paraffin-embedded lung tissue samples were obtained from 47 patients with IIPs, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), and cryptogenic organizing pneumonia (COP), and 12 normal controls were immunohistochemically analyzed, using primary antibodies against CD68 and CD163 as indicators of pan and M2 macrophages, respectively.
Results.
CD68+ macrophage density was significantly increased in the 3 subtypes of IIPs relative to that in the control group, although no difference was detected within the different IIPs.
CD163+ macrophage density was significantly increased in NSIP and COP samples relative to that in IPF samples.
The density ratio of CD163+ macrophages to CD68+ macrophages was significantly decreased in IPF/UIP samples relative to that in the others, while the densities in NSIP and COP were significantly higher than those in control cases.
Conclusion.
CD163+ macrophages show distinct profiles among IIPs, and the standardized numerical density is decreased in IPF cases that have poor prognoses.
American Psychological Association (APA)
Yamashita, Masahiro& Saito, Ryoko& Yasuhira, Shinji& Fukuda, Yuh& Sasano, Hironobu& Sugai, Tamotsu…[et al.]. 2018. Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1191581
Modern Language Association (MLA)
Yamashita, Masahiro…[et al.]. Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1191581
American Medical Association (AMA)
Yamashita, Masahiro& Saito, Ryoko& Yasuhira, Shinji& Fukuda, Yuh& Sasano, Hironobu& Sugai, Tamotsu…[et al.]. Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1191581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191581