RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-α through NF-κβ and AP-1 in Two Cell Lines of Breast Cancer
Joint Authors
Delgado-Lopez, Fernando
Rojas, A.
Gonzalez, I.
Perez, R.
Añasco, C.
Romero, J.
Araya, P.
Santos, L. S.
Monsalve, Francisco A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses.
RID downregulates the cell surface expression of epidermal growth factor receptor (EGFR), tumor necrosis factor receptor (TNFR), and apoptosis antigen 1 (FAS), causing a reduction of the effects of their respective ligands.
In addition, RID inhibits apoptosis by decreasing the secretion of TNF-related apoptosis-inducing ligand (TRAIL) by normal tissue cells.
In this article, we report that RID inhibited chemokine expression in human breast cancer cell line MDA-MB-231 but showed no effect in cell line MCF7.
These dissimilar results may be due to the different molecular and functional properties of both cell lines.
Therefore, it is necessary to replicate this study in other breast cancer cell models.
American Psychological Association (APA)
Monsalve, Francisco A.& Rojas, A.& Gonzalez, I.& Perez, R.& Añasco, C.& Romero, J.…[et al.]. 2020. RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-α through NF-κβ and AP-1 in Two Cell Lines of Breast Cancer. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191595
Modern Language Association (MLA)
Monsalve, Francisco A.…[et al.]. RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-α through NF-κβ and AP-1 in Two Cell Lines of Breast Cancer. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191595
American Medical Association (AMA)
Monsalve, Francisco A.& Rojas, A.& Gonzalez, I.& Perez, R.& Añasco, C.& Romero, J.…[et al.]. RID: Evaluation of the Possible Inhibiting Effect of the Proinflammatory Signaling Induced by TNF-α through NF-κβ and AP-1 in Two Cell Lines of Breast Cancer. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191595
