Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan’s Syndrome
Joint Authors
Shamriz, Oded
Tal, Yuval
Gross, Menachem
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cogan’s syndrome (CS) is a rare autoimmune disorder characterized by audiovestibular dysfunction and ocular inflammation.
Currently, there is no specific serum autoantibody used in the diagnostic workup of CS.
Treatment is based on immunosuppressive agents, mainly corticosteroids as first-line choice.
Recently, novel therapeutic modalities in CS have emerged.
These include tumor necrosis factor-α inhibitors and other biologicals.
Despite medical treatment, hearing loss may progress to irreversible bilateral profound SNHL in approximately half of CS patients resulting in candidacy for cochlear implantation (CI).
Due to the inflammatory nature of the disease that is causing endosteal reaction with partial obliteration or complete neoossification of the intracochlear ducts, early CI is recommended.
CI provides excellent and stable hearing rehabilitation with high score of word and sentence recognition.
In this review, we will discuss different aspects of CS including clinical presentation, diagnosis, treatment, and future directives.
American Psychological Association (APA)
Shamriz, Oded& Tal, Yuval& Gross, Menachem. 2018. Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan’s Syndrome. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1191606
Modern Language Association (MLA)
Shamriz, Oded…[et al.]. Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan’s Syndrome. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1191606
American Medical Association (AMA)
Shamriz, Oded& Tal, Yuval& Gross, Menachem. Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan’s Syndrome. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1191606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191606