Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population
Joint Authors
Dursun, Recep
Dursun, Hatice Gül
Kulaksızoğlu, Sevsen
Yılmaz, Hüseyin Osman
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Psoriasis is a common, chronic, and autoimmune skin disease in which dysregulation of immune cells, particularly T cells, is thought to play an important role in the pathogenesis.
Cytotoxic T lymphocyte antigen-4 (CTLA-4) expressed only on activated T cells is an immunoregulatory molecule and plays a role in the pathogenesis of autoimmune disorders.
We aimed to determine whether CTLA-4 gene polymorphisms are associated with development and/or clinical features of psoriasis vulgaris (Pv).
Genotyping of SNPs (−318C>T, +49A>G, and CT60A>G) in CTLA-4 gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 103 Pv patients and 102 controls.
No statistically significant associations were detected in any of the investigated genetic models for the −318C>T polymorphism.
The genotype distributions of +49A>G and CT60A>G were associated with Pv development.
In haplotype analysis, while frequency of CAA haplotype was significantly higher in the control group, frequencies of CGG and CAG haplotype were significantly higher among the patients.
However, all of CTLA-4 polymorphisms and haplotypes do not have an effect on severity and onset age of Pv.
In conclusion, the +49A>G and CT60A>G polymorphisms may be risk factors for Pv development.
Furthermore, CGG and CAG haplotypes may contribute to Pv development, while CAA haplotype may be protective against Pv.
American Psychological Association (APA)
Dursun, Hatice Gül& Yılmaz, Hüseyin Osman& Dursun, Recep& Kulaksızoğlu, Sevsen. 2018. Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1191657
Modern Language Association (MLA)
Dursun, Hatice Gül…[et al.]. Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1191657
American Medical Association (AMA)
Dursun, Hatice Gül& Yılmaz, Hüseyin Osman& Dursun, Recep& Kulaksızoğlu, Sevsen. Association of Cytotoxic T Lymphocyte Antigen-4 Gene Polymorphisms with Psoriasis Vulgaris: A Case-Control Study in Turkish Population. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1191657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191657