The Interplay between Immune System and Microbiota in Osteoporosis
Joint Authors
Paragliola, Rosa Maria
Locantore, Pietro
Del Gatto, Valeria
Gelli, Silvia
Pontecorvi, Alfredo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Osteoporosis is a disease characterized by low bone mass and alterations of bone microarchitecture, with an increased risk of fractures.
It is a multifactorial disorder that is more frequent in postmenopausal women but can be associated to other diseases (inflammatory and metabolic diseases).
At present, several options are available to treat osteoporosis trying to block bone reabsorption and reduce the risk of fracture.
Anyway, these drugs have safety and tolerance problems in long-term treatment.
Recently, gut microbiota has been highlighted to have strong influence on bone metabolism, becoming a potential new target to modify bone mineral density.
Such evidences are mainly based on mouse models, showing an involvement in modulating the interaction between the immune system and bone cells.
Germ-free mice represent a basic model to understand the interaction between microbiota, immune system, and bone cells, even though data are controversial.
Anyway, such models have unequivocally demonstrated a connection between such systems, even if the mechanism is unclear.
Gut microbiota is a complex system that influences calcium and vitamin D absorption and modulates gut permeability, hormonal secretion, and immune response.
A key role is played by the T helper 17 lymphocytes, TNF, interleukin 17, and RANK ligand system.
Other important pathways include NOD1, NOD2, and Toll-like receptor 5.
Prebiotics and probiotics are a wide range of substances and germs that can influence and modify microbiota.
Several studies demonstrated actions by different prebiotics and probiotics in different animals, differing according to sex, age, and hormonal status.
Data on the effects on humans are poor and controversial.
Gut microbiota manipulation appears a possible strategy to prevent and treat osteopenia and/or osteoporosis as well as other possible bone alterations, even though further clinical studies are necessary to identify correct procedures in humans.
American Psychological Association (APA)
Locantore, Pietro& Del Gatto, Valeria& Gelli, Silvia& Paragliola, Rosa Maria& Pontecorvi, Alfredo. 2020. The Interplay between Immune System and Microbiota in Osteoporosis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191695
Modern Language Association (MLA)
Locantore, Pietro…[et al.]. The Interplay between Immune System and Microbiota in Osteoporosis. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191695
American Medical Association (AMA)
Locantore, Pietro& Del Gatto, Valeria& Gelli, Silvia& Paragliola, Rosa Maria& Pontecorvi, Alfredo. The Interplay between Immune System and Microbiota in Osteoporosis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191695