Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients
Joint Authors
Chen, Dan
Sun, Wenwu
Li, Jia
Wei, Bohua
Liu, Wei
Wang, Xiaopin
Song, Fan
Chen, Liangkai
Yang, Junhui
Yu, Li
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) and investigating the potential prognostic value of serum cystatin C in adult patients with COVID-19.
481 patients with COVID-19 were consecutively included in this study from January 2, 2020, and followed up to April 15, 2020.
All clinical and laboratory data of COVID-19 patients with definite outcomes were reviewed.
For every measure, COVID-19 patients were grouped into quartiles according to the baseline levels of serum cystatin C.
The highest cystatin C level was significantly related to more severe inflammatory conditions, worse organ dysfunction, and worse outcomes among patients with COVID-19 (P values < 0.05).
In the adjusted logistic regression analyses, the highest cystatin C level and ln-transformed cystatin C levels were independently associated with the risks of developing critically ill COVID-19 and all-cause death either in overall patients or in patients without chronic kidney disease (P values < 0.05).
As a potential inflammatory marker, increasing baseline levels of serum cystatin C might independently predict adverse outcomes for COVID-19 patients.
Serum cystatin C could be routinely monitored during hospitalization, which showed clinical importance in prognosticating for adult patients with COVID-19.
American Psychological Association (APA)
Chen, Dan& Sun, Wenwu& Li, Jia& Wei, Bohua& Liu, Wei& Wang, Xiaopin…[et al.]. 2020. Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191700
Modern Language Association (MLA)
Chen, Dan…[et al.]. Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients. Mediators of Inflammation No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1191700
American Medical Association (AMA)
Chen, Dan& Sun, Wenwu& Li, Jia& Wei, Bohua& Liu, Wei& Wang, Xiaopin…[et al.]. Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1191700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191700