Higher Levels of High-Sensitivity C-Reactive Protein Is Positively Associated with the Incidence of Hyperuricemia in Chinese Population: A Report from the China Health and Retirement Longitudinal Study

Abstract EN

Purpose.

The aim of the present cohort study was to explore the longitudinal association between high-sensitivity C-reactive protein (CRP) and hyperuricemia in Chinese population.

Furthermore, we conducted subgroup analyses to explore this association according to age, sex, and body mass index.

Methods.

A total of 5,419 healthy participants were enrolled in the final cohort analysis.

The high-sensitivity CRP level was measured by immunoturbidimetric assay.

Hyperuricemia was defined as serum uric acid ≥7.0 mg/dL (416 μmol/L) in men and ≥6.0 mg/dL (357 μmol/L) in women.

Multivariate logistic regression was used to analyze the association.

Results.

During the 4 years follow-up, 474 participants developed hyperuricemia.

Compared with participants in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted odds ratio (OR) (95% confidence interval [CI]) for incident hyperuricemia in the highest tertile was 1.36 (1.02, 1.82).

In the subgroup analyses, high-sensitivity CRP was positively associated with the incidence of hyperuricemia after multivariate adjustments (P for trend=0.04) in women.

Compared with the women in the lowest tertile of high-sensitivity CRP, the multivariate-adjusted OR (95% CI) in the highest tertile was 1.69 (1.10, 2.66).

No statistically significant association was found in other subgroups.

Conclusions.

The findings of this prospective cohort study suggest that higher level of high-sensitivity CRP is an independent risk factor for hyperuricemia in Chinese, especially in women.