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Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROSNF-κBNLRP3 Axis in Renal Tubular Epithelial Cells
Joint Authors
Peng, Fen-Fen
Xu, Zhao-Zhong
Chen, Yi-hua
Lei, Xianghong
Li, Shuting
Luo, Congwei
Wang, Yuxian
Liu, Yanxia
Huang, Qianyin
Zou, Fangqin
Long, Haibo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chronic kidney disease is a common disease closely related to renal tubular inflammation and oxidative stress, and no effective treatment is available.
Activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is an important factor in renal inflammation, but the mechanism remains unclear.
Micheliolide (MCL), which is derived from parthenolide, is a new compound with antioxidative and anti-inflammatory effects and has multiple roles in tumors and inflammatory diseases.
In this study, we investigated the effect of MCL on lipopolysaccharide- (LPS-) induced inflammation in renal tubular cells and the related mechanism.
We found that MCL significantly suppressed the LPS-induced NF-κB signaling and inflammatory expression of cytokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1 in a rat renal proximal tubular cell line (NRK-52E).
MCL also prevented LPS- and adenosine triphosphate-induced NLRP3 inflammasome activation in vitro, as evidenced by the inhibition of NLRP3 expression, caspase-1 cleavage, and interleukin-1β and interleukin-18 maturation and secretion.
Additionally, MCL inhibited the reduction of mitochondrial membrane potential and decreases the release of reactive oxygen species (ROS).
Moreover, MCL can prevent NLRP3 inflammasome activation induced by rotenone, a well-known mitochondrial ROS (mROS) agonist, indicating that the mechanism of MCL’s anti-inflammatory effect may be closely related to the mROS.
In conclusion, our study indicates that MCL can inhibit LPS-induced renal inflammation through suppressing the mROS/NF-κB/NLRP3 axis in tubular epithelial cells.
American Psychological Association (APA)
Lei, Xianghong& Li, Shuting& Luo, Congwei& Wang, Yuxian& Liu, Yanxia& Xu, Zhao-Zhong…[et al.]. 2020. Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROSNF-κBNLRP3 Axis in Renal Tubular Epithelial Cells. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191711
Modern Language Association (MLA)
Lei, Xianghong…[et al.]. Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROSNF-κBNLRP3 Axis in Renal Tubular Epithelial Cells. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191711
American Medical Association (AMA)
Lei, Xianghong& Li, Shuting& Luo, Congwei& Wang, Yuxian& Liu, Yanxia& Xu, Zhao-Zhong…[et al.]. Micheliolide Attenuates Lipopolysaccharide-Induced Inflammation by Modulating the mROSNF-κBNLRP3 Axis in Renal Tubular Epithelial Cells. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191711