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Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling
Joint Authors
Hong, Jin
Li, Pengcheng
Liu, Yuzhou
Dong, Jianzeng
Wang, Mengyu
Xing, Junhui
Gao, Yueqiao
Gu, Heping
Li, Ling
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ubiquitin-specific protease 2 (USP2) is an important member of the deubiquitination system.
GEO dataset revealed that USP2 was downregulated in the hearts under pressure overload.
However, the cardiomyocyte-specific function of USP2 in the setting of pressure overload is unknown.
In the current study, a mouse model of pressure overload was induced by transverse aortic constriction (TAC, 2 weeks).
Overexpression of USP2 in the heart was conducted by AAV9 infection.
Changes in heart histology were detected by Masson’s trichrome staining and hematoxylin-eosin staining (H&E).
Echocardiography was used to assess cardiac function.
The size of cardiomyocytes was examined by wheat germ agglutinin (WGA) staining.
Cardiac oxidative stress was detected by dihydroethidine staining.
Our results showed that USP2 was downregulated in the cardiomyocytes following 2 weeks of TAC.
Overexpression of cardiac USP2 preserved ventricular function following 2 weeks of TAC.
Overexpression of cardiac USP2 inhibited TAC-induced cardiac remodeling, by suppressing cardiac hypertrophy, inhibiting inflammatory responses and fibrosis, and attenuating oxidative stress.
Our findings reveal a previously unrecognized role of USP2 in regulating pressure overload-induced cardiac remodeling.
American Psychological Association (APA)
Xing, Junhui& Li, Pengcheng& Hong, Jin& Wang, Mengyu& Liu, Yuzhou& Gao, Yueqiao…[et al.]. 2020. Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191722
Modern Language Association (MLA)
Xing, Junhui…[et al.]. Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1191722
American Medical Association (AMA)
Xing, Junhui& Li, Pengcheng& Hong, Jin& Wang, Mengyu& Liu, Yuzhou& Gao, Yueqiao…[et al.]. Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1191722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191722