Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity
Joint Authors
Sette, Alessandro
Peters, Bjoern
Vaughan, Kerrie
Xu, Xiaojun
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The global response to the most recent EBOV outbreak has led to increased generation and availability of data, which can be globally analyzed to increase our understanding of immune responses to EBOV.
We analyzed the published antibody epitope data to identify regions immunogenic for humans on the main GP antigenic target and determine sequence variance/nonsynonymous mutations between historical isolates and variants from the 2013-2016 outbreak.
Approximately half of the GP sequence has been reported as targeted by antibody responses.
Our results show an enrichment of nonsynonymous mutations (NSMs) within epitopic regions on GP (70%, p=0.0133).
Mapping NSMs to human epitope reactivity may be useful for future therapeutic and prophylaxis development as well as for our general understanding of immunity against EBOV.
American Psychological Association (APA)
Vaughan, Kerrie& Xu, Xiaojun& Peters, Bjoern& Sette, Alessandro. 2018. Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1191728
Modern Language Association (MLA)
Vaughan, Kerrie…[et al.]. Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1191728
American Medical Association (AMA)
Vaughan, Kerrie& Xu, Xiaojun& Peters, Bjoern& Sette, Alessandro. Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1191728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191728