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miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis
Joint Authors
Cabrera, Wafa H. K.
Ribeiro, Orlando G.
Jensen, José Ricardo
Ibañez, Olga M.
Starobinas, Nancy
Correa, Mara A.
Borrego, Andrea
Fernandes, Jussara G.
De Franco, Marcelo
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Pristane-induced arthritis (PIA) in mice is an experimental model that resembles human rheumatoid arthritis, a chronic autoimmune disease that affects joints and is characterized by synovial inflammation and articular cartilage and bone destruction.
AIRmax and AIRmin mouse lines differ in their susceptibility to PIA, and linkage analysis in this model mapped arthritis severity QTLs in chromosomes 5 and 8.
miRNAs are a class of small RNA molecules that have been extensively studied in the development of arthritis.
We analyzed miRNA and gene expression profiles in peritoneal cells of AIRmax and AIRmin lines, in order to evaluate the genetic architecture in this model.
Susceptible AIRmax mice showed higher gene (2025 vs 1043) and miRNA (240 vs 59) modulation than resistant AIRmin mice at the onset of disease symptoms.
miR-132-3p/212-3p, miR-106-5p, miR-27b-3p, and miR-25-3p were among the miRNAs with the highest expression in susceptible animals, showing a negative correlation with the expression of predicted target genes (Il10, Cd69, and Sp1r1).
Our study showed that global gene and miRNA expression profiles in peritoneal cells of susceptible AIRmax and resistant AIRmin lines during pristane-induced arthritis are distinct, evidencing interesting targets for further validation.
American Psychological Association (APA)
Fernandes, Jussara G.& Borrego, Andrea& Jensen, José Ricardo& Cabrera, Wafa H. K.& Correa, Mara A.& Starobinas, Nancy…[et al.]. 2018. miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1191731
Modern Language Association (MLA)
Fernandes, Jussara G.…[et al.]. miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1191731
American Medical Association (AMA)
Fernandes, Jussara G.& Borrego, Andrea& Jensen, José Ricardo& Cabrera, Wafa H. K.& Correa, Mara A.& Starobinas, Nancy…[et al.]. miRNA Expression and Interaction with Genes Involved in Susceptibility to Pristane-Induced Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1191731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191731