IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis
Joint Authors
Hoving, Jennifer Claire
Keeton, Roanne
Höft, Maxine A.
Ozturk, Mumin
Otieno-Odhiambo, Patricia
Brombacher, Frank
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A hallmark of ulcerative colitis is the chronic colonic inflammation, which is the result of a dysregulated intestinal mucosal immune response.
Epithelial barrier disruption which allows the entry of microorganisms eventually leads to more aggressive inflammation and potentially the removal of the colon.
We have previously shown that the T helper- (Th-) type 2 cytokines, Interleukin- (IL-) 4 and IL-13, mediate CD4+ T cell- or B cell-driven inflammation in the oxazolone-induced mouse model of ulcerative colitis.
In contrast, mice deficient in the shared receptor of IL-4 and IL-13, IL-4 receptor-alpha (IL-4Rα), on all cells develop an exacerbated disease phenotype.
This suggests that a regulatory role of IL-4Rα is required to protect against severe colitis.
However, the cell populations responsible for regulating the severity of disease onset through IL-4Rα in colitis are yet to be identified.
By deleting IL-4Rα on specific cell subsets shown to play a role in mediating colitis, we determined their role in a loss of function approach.
Our data demonstrated that the loss of IL-4Rα signalling on intestinal epithelial cells, smooth muscle cells, and macrophages/neutrophils had no effect on alleviating the pathology associated with colitis.
These results suggest that IL-4/IL-13 signalling through IL-4Rα on nonhematopoietic intestinal epithelial or smooth muscle cells and hematopoietic macrophage/neutrophils has a redundant role in driving acute oxazolone colitis.
American Psychological Association (APA)
Hoving, Jennifer Claire& Keeton, Roanne& Höft, Maxine A.& Ozturk, Mumin& Otieno-Odhiambo, Patricia& Brombacher, Frank. 2020. IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191759
Modern Language Association (MLA)
Hoving, Jennifer Claire…[et al.]. IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191759
American Medical Association (AMA)
Hoving, Jennifer Claire& Keeton, Roanne& Höft, Maxine A.& Ozturk, Mumin& Otieno-Odhiambo, Patricia& Brombacher, Frank. IL-4 Receptor-Alpha Signalling of Intestinal Epithelial Cells, Smooth Muscle Cells, and Macrophages Plays a Redundant Role in Oxazolone Colitis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191759