Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Trimethylamine N-oxide (TMAO) is a biologically active molecule generated by the gut microbiota.
Accumulating evidences have indicated a close association between high plasma TMAO levels and the risk of developing atherosclerosis (AS).
AS is considered a chronic inflammatory disease initiated by vascular endothelial inflammatory injury.
Both observational and experimental studies suggest that TMAO can cause endothelial inflammatory injury.
However, a clear mechanistic link between TMAO and vascular inflammation of AS is not yet summarized.
In this review, we discuss the association between TMAO and AS and focus on the potential role of TMAO in endothelial inflammatory injury.
Finally, the utility of TMAO-targeted therapeutic strategies for the treatment of AS is also analyzed.
American Psychological Association (APA)
Liu, Yarong& Dai, Min. 2020. Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1191773
Modern Language Association (MLA)
Liu, Yarong& Dai, Min. Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis. Mediators of Inflammation No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1191773
American Medical Association (AMA)
Liu, Yarong& Dai, Min. Trimethylamine N-Oxide Generated by the Gut Microbiota Is Associated with Vascular Inflammation: New Insights into Atherosclerosis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1191773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191773