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Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients
Joint Authors
Alkahtani, Saad
Darraj, Majid
Aljarba, Nada H.
Shafeai, Mohammed I.
Rudiny, Fuad H.
Bin Dajem, Saad M.
Alothaid, Hani
Alghamdi, Jahad
Al-Ahdal, Mohammed N.
al-Anazi, Mashael R.
al-Qahtani, Ahmed A.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Background and Objectives.
Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications.
Interleukin-22 (IL-22) has been implicated in several diseases including malaria.
The objective of this study was to investigate the role of IL-22 gene polymorphisms in P.
falciparum infection.
Material and Methods.
Ten single-nucleotide polymorphisms (SNPs), rs976748, rs1179246, rs2046068, rs1182844, rs2227508, rs2227513, rs2227478, rs2227481, rs2227491, and rs2227483, of IL-22 gene were genotyped through PCR-based assays of 250 P.
falciparum-infected patients and 200 healthy controls.
In addition, a luciferase reporter assay was done to assess the role of the rs2227513 SNP in IL-22 gene promoter activity.
Results.
We found that the rs2227481 TT genotype (odds ratio 0.254, confidence interval = 0.097-0.663, P=0.002) and the T allele is associated with protection against P.
falciparum malaria as well as the rs2227483 AT genotype (odds ratio 0.375, confidence interval = 0.187-0.754, P=0.004).
The haplotype A-T-T of rs1179246, rs1182844, and rs976748 was statistically more frequent in the control group (frequency 41%, P=0.034) as well as the haplotype A-G of rs2046068 and rs2227491 (frequency 49.4%, P=0.041).
The variant rs2227513 G allele had a statistically higher activity (P<0.0001) with the luciferase reporter assay.
Conclusion.
The study suggests that IL-22 polymorphisms in rs2227481 and rs2227483 could contribute to protection against P.
falciparum malaria.
Also, the G allele of rs2227513, located in the promoter region of IL-22 gene, could be essential for higher expression levels of IL-22 cytokine.
American Psychological Association (APA)
Aljarba, Nada H.& al-Anazi, Mashael R.& Shafeai, Mohammed I.& Rudiny, Fuad H.& Bin Dajem, Saad M.& Alothaid, Hani…[et al.]. 2020. Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1191801
Modern Language Association (MLA)
Aljarba, Nada H.…[et al.]. Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients. Mediators of Inflammation No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1191801
American Medical Association (AMA)
Aljarba, Nada H.& al-Anazi, Mashael R.& Shafeai, Mohammed I.& Rudiny, Fuad H.& Bin Dajem, Saad M.& Alothaid, Hani…[et al.]. Interleukin-22 Polymorphisms in Plasmodium falciparum-Infected Malaria Patients. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1191801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191801