Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma
Joint Authors
Jurczyszyn, Artur
Krzanowski, Marcin
Kuźniewski, Marek
Banaszkiewicz, Małgorzata
Małyszko, Jolanta
Batko, Krzysztof
Koc-Żórawska, Ewa
Żórawski, Marcin
Woziwodzka, Karolina
Tisończyk, Joanna
Małyszko, Jacek
Waszczuk-Gajda, Anna
Drożdż, Ryszard
Krzanowska, Katarzyna
Dumnicka, Paulina
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor-β superfamily, participates in processes associated with myeloma development and its end-organ complications.
It plays a significant role in both physiological and abnormal erythropoiesis and regulates iron homeostasis through modulation of hepcidin.
It is abnormally secreted in marrow stromal cells of patients with multiple myeloma (MM), which may reflect the tumor microenvironment.
We analyzed the associations of serum GDF-15 with clinical characteristics of 73 MM patients (including asymptomatic MM) and the laboratory indices of renal function, anemia, and inflammation.
Baseline serum GDF-15 was studied as the predictor of two-year survival.
We defined five clinically relevant subgroups of patients (symptomatic MM only, patients with and without remission, patients on chemotherapy, and without treatment).
Increased GDF-15 concentrations were associated with more advanced MM stage, anemia, renal impairment (lower glomerular filtration and higher markers of tubular injury), and inflammation.
Most of the results were confirmed in the subgroup analysis.
Serum cystatin C and urine neutrophil gelatinase-associated lipocalin were associated with GDF-15 independently of other variables.
In the studied MM patients, GDF-15 did not significantly predict survival (p=0.06).
Our results suggest that serum GDF-15 reflects myeloma burden and shares a relationship with several markers of prognostic significance, as well as major manifestations.
American Psychological Association (APA)
Żórawski, Marcin& Dumnicka, Paulina& Jurczyszyn, Artur& Woziwodzka, Karolina& Tisończyk, Joanna& Krzanowski, Marcin…[et al.]. 2020. Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1191825
Modern Language Association (MLA)
Żórawski, Marcin…[et al.]. Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma. Mediators of Inflammation No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1191825
American Medical Association (AMA)
Żórawski, Marcin& Dumnicka, Paulina& Jurczyszyn, Artur& Woziwodzka, Karolina& Tisończyk, Joanna& Krzanowski, Marcin…[et al.]. Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1191825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191825