Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases
Joint Authors
Tanase, Cristiana Pistol
Albulescu, Lucian
Mihai, Simona
Popescu, Ionela Daniela
Enciu, Ana-Maria
Hinescu, Mihail Eugen
Codrici, Elena
Albulescu, Radu
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Caveolin-1 (CAV1) is the scaffold protein of caveolae, which are minute invaginations of the cell membrane that are involved in endocytosis, cell signaling, and endothelial-mediated inflammation.
CAV1 has also been reported to have a dual role as either a tumor suppressor or tumor promoter, depending on the type of cancer.
Inflammation is an important player in tumor progression, but the role of caveolin-1 in generating an inflammatory milieu remains poorly characterized.
We used a caveolin-1-knockout (CAV1−/−) mouse model to assess the inflammatory status via the quantification of the pro- and anti-inflammatory cytokine levels, as well as the ability of circulating lymphocytes to respond to nonspecific stimuli by producing cytokines.
Here, we report that the CAV1−/− mice were characterized by a low-grade systemic proinflammatory status, with a moderate increase in the IL-6, TNF-α, and IL-12p70 levels.
CAV1−/− circulating lymphocytes were more prone to cytokine production upon nonspecific stimulation than the wild-type lymphocytes.
These results show that CAV1 involvement in cell homeostasis is more complex than previously revealed, as it plays a role in the inflammatory process.
These findings indicate that the CAV1−/− mouse model could prove to be a useful tool for inflammation-related studies.
American Psychological Association (APA)
Codrici, Elena& Albulescu, Lucian& Popescu, Ionela Daniela& Mihai, Simona& Enciu, Ana-Maria& Albulescu, Radu…[et al.]. 2018. Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1191836
Modern Language Association (MLA)
Codrici, Elena…[et al.]. Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1191836
American Medical Association (AMA)
Codrici, Elena& Albulescu, Lucian& Popescu, Ionela Daniela& Mihai, Simona& Enciu, Ana-Maria& Albulescu, Radu…[et al.]. Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1191836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191836