Association of Brain-Gut Peptides with Inflammatory Cytokines in Moyamoya Disease
Joint Authors
Jiang, Pei
Jin, Feng
Cui, Changmeng
Han, Wenxiu
Zhang, Hailiang
Yang, Mengqi
Wang, Changshui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Systemic inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MMD).
Brain-gut peptides exhibit regulatory effects in the secretion of proinflammatory cytokines.
To investigate the association between brain-gut peptides and inflammation in the occurrence of MMD, 41 patients with MMD, as well as 74 age- and sex-matched healthy individuals were enrolled.
The levels of four brain-gut peptides (vasoactive intestinal polypeptide (VIP), cholecystokinin (CCK), somatostatin (SST), substance P (SP)) and three proinflammatory cytokines (interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), IL-12) in the serum and cerebrospinal fluid (CSF) were measured using the enzyme-linked immunosorbent assay.
The associations between brain-gut peptides and proinflammatory cytokines were estimated according to the multiple linear regression and correlation analyses.
MMD patients exhibited significantly lower levels of VIP, CCK, and SST and higher levels of IL-1β, TNF-α, and IL-12 in the serum compared with healthy controls.
Multiple logistic regression analysis showed that decreased VIP, CCK, and SST levels were independent predictors of the occurrence of MMD.
Negative correlations were observed between the VIP and proinflammatory cytokines, including IL-1β, TNF-α, and IL-12 (serum vs.
CSF).
Significant negative correlations were also found between CCK and IL-1β, as well as IL-12 (serum vs.
CSF).
SST was negatively correlated with IL-1β and TNF-α in the serum and IL-1β only in the CSF.
In addition, the levels of VIP, CCK, SST, and proinflammatory cytokines IL-1β and TNF-α in the serum were correlated with those measured in the CSF.
Collectively, lower levels of VIP, CCK, and SST may be associated with the pathogenesis of MMD and act as clinically useful biomarkers along with the levels of proinflammatory cytokines.
American Psychological Association (APA)
Han, Wenxiu& Jin, Feng& Zhang, Hailiang& Yang, Mengqi& Cui, Changmeng& Wang, Changshui…[et al.]. 2020. Association of Brain-Gut Peptides with Inflammatory Cytokines in Moyamoya Disease. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191843
Modern Language Association (MLA)
Han, Wenxiu…[et al.]. Association of Brain-Gut Peptides with Inflammatory Cytokines in Moyamoya Disease. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191843
American Medical Association (AMA)
Han, Wenxiu& Jin, Feng& Zhang, Hailiang& Yang, Mengqi& Cui, Changmeng& Wang, Changshui…[et al.]. Association of Brain-Gut Peptides with Inflammatory Cytokines in Moyamoya Disease. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191843