Regulation of Iron Homeostasis and Related Diseases
Joint Authors
Wan, Dan
Li, Yikun
Huang, Xiali
Wang, Jingjing
Huang, R. L.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The liver is the organ for iron storage and regulation; it senses circulating iron concentrations in the body through the BMP-SMAD pathway and regulates the iron intake from food and erythrocyte recovery into the bloodstream by secreting hepcidin.
Under iron deficiency, hypoxia, and hemorrhage, the liver reduces the expression of hepcidin to ensure the erythropoiesis but increases the excretion of hepcidin during infection and inflammation to reduce the usage of iron by pathogens.
Excessive iron causes system iron overload; it accumulates in never system and damages neurocyte leading to neurodegenerative diseases such as Parkinson’s syndrome.
When some gene mutations affect the perception of iron and iron regulation ability in the liver, then they decrease the expression of hepcidin, causing hereditary diseases such as hereditary hemochromatosis.
This review summarizes the source and utilization of iron in the body, the liver regulates systemic iron homeostasis by sensing the circulating iron concentration, and the expression of hepcidin regulated by various signaling pathways, thereby understanding the pathogenesis of iron-related diseases.
American Psychological Association (APA)
Li, Yikun& Huang, Xiali& Wang, Jingjing& Huang, R. L.& Wan, Dan. 2020. Regulation of Iron Homeostasis and Related Diseases. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191862
Modern Language Association (MLA)
Li, Yikun…[et al.]. Regulation of Iron Homeostasis and Related Diseases. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1191862
American Medical Association (AMA)
Li, Yikun& Huang, Xiali& Wang, Jingjing& Huang, R. L.& Wan, Dan. Regulation of Iron Homeostasis and Related Diseases. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1191862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191862