Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity
Joint Authors
Lu, Xin
Wang, Guochun
Shu, Xiaoming
He, Linrong
Liu, Xia
Ge, Yongpeng
Li, Sizhao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To investigate the role of soluble interleukin-2R (sIL-2R) in idiopathic inflammatory myopathies (IIM).
Methods.
Serum sIL-2R levels were measured in 74 dermatomyositis (DM), 16 immune-mediated necrotizing myopathy (IMNM), 24 rheumatoid arthritis (RA), 20 systemic lupus erythematosus (SLE), and 20 healthy controls (HCs) by chemiluminescent immunometric assay.
Clinical features and laboratory data were collected from electronic medical record.
Disease activity was evaluated by using physician global disease activity and myositis disease activity assessment visual analog scale (MYOACT) on admission.
20 DM patients were followed.
Serum sIL-2R levels were analyzed and compared with clinical features, laboratory data, and measures of disease activity.
Results.
Serum sIL-2R levels were significantly higher in DM patients than in IMNM patients and HCs (648.8±433.1 U/ml vs.
352.3±126.0 U/ml and 648.8±433.1 U/ml vs.
285.8±101.9 U/ml, respectively; all P<0.001), while there was no significant difference between IMNM and HCs.
There were also no significant differences of sIL-2R levels in DM, SLE, and RA.
Importantly, serum sIL-2R levels were significantly higher in treatment-naïve or active DM patients than those that are not (1100.9±550.4 U/ml vs.
615.6±330.4 U/ml, P=0.006; 808.8±421.6 U/ml vs.
339.8±103.4 U/ml, P<0.001).
DM patients with skin ulcers had significantly higher sIL-2R levels than those without (889.3±509.9 U/ml vs.
640.0±368.7 U/ml, P=0.023).
Cross-sectional analysis in DM showed that sIL-2R levels positively correlated with CK, ESR, CRP, ferritin, physician VAS, and MYOACT scores (rho=0.278, rho=0.474, rho=0.469, rho=0.454, r=0.646, and r=0.600, respectively; all P<0.05), negatively correlated with T cell counts and MMT8 scores (r=−0.380, P=0.002; rho=−0.394, P=0.001).
Follow-up study showed that changes in sIL-2R levels after treatment correlated with changes in physician VAS and MYOACT scores (r=0.823 and r=0.695, respectively; all P<0.01).
Conclusion.
Serum sIL-2R levels were elevated in DM but not in IMNM.
Serum sIL-2R could act as a disease activity marker and be associated with ulcerative skin lesions in DM.
American Psychological Association (APA)
He, Linrong& Shu, Xiaoming& Liu, Xia& Ge, Yongpeng& Li, Sizhao& Lu, Xin…[et al.]. 2020. Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191874
Modern Language Association (MLA)
He, Linrong…[et al.]. Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191874
American Medical Association (AMA)
He, Linrong& Shu, Xiaoming& Liu, Xia& Ge, Yongpeng& Li, Sizhao& Lu, Xin…[et al.]. Soluble IL-2 Receptor in Dermatomyositis: Its Associations with Skin Ulcers and Disease Activity. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191874