Research Progress on NK Cell Receptors and Their Signaling Pathways
Joint Authors
Fu, Rong
Chen, Yingying
Lu, Dan
Churov, Alexey
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Natural killer cells (NK cells) play an important role in innate immunity.
NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors.
After binding to their ligands, NK cell receptors trigger subsequent signaling conduction and then determine whether NK is activated or inhibited.
Furthermore, NK cell response includes cytotoxicity and cytokine release, which is tightly related to the activation of NK cell-activating receptors and the inhibition of inhibitory receptors on the surfaces of NK cells.
The expression and function of NK cell surface receptors also alter in virus infection, tumor, and autoimmune diseases and influence the occurrence and development of diseases.
So, it is important to understand the mechanism of recognition between NK receptors and their ligands in pathological conditions and the signaling pathways of NK cell receptors.
This review mainly summarizes the research progress on NK cell surface receptors and their signal pathways.
American Psychological Association (APA)
Chen, Yingying& Lu, Dan& Churov, Alexey& Fu, Rong. 2020. Research Progress on NK Cell Receptors and Their Signaling Pathways. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1191903
Modern Language Association (MLA)
Chen, Yingying…[et al.]. Research Progress on NK Cell Receptors and Their Signaling Pathways. Mediators of Inflammation No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1191903
American Medical Association (AMA)
Chen, Yingying& Lu, Dan& Churov, Alexey& Fu, Rong. Research Progress on NK Cell Receptors and Their Signaling Pathways. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1191903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191903