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Nicotine Impairs the Response of Lung Epithelial Cells to IL-22
Joint Authors
Agrawal, Anshu
Agrawal, Sudhanshu
Nguyen, Hannah My-Hanh
Torres, Jaclene Amber
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Smoking is a major risk factor for pulmonary diseases that include chronic obstructive pulmonary diseases (COPD) and cancer.
Nicotine is the toxic and addictive component of tobacco products, like cigarettes, that negatively affects the immune system.
Here, we examined the effect of nicotine on the IL-22 pathway that protects lung function by increasing transepithelial resistance and epithelial cell regeneration and repair.
Our results indicate that exposure to nicotine impairs the regenerative capacity of primary bronchial epithelial cells in scratch assays.
IL-22 at 100 ng/ml significantly improved wound healing in epithelial cells; however, the exposure to nicotine hampered the IL-22-mediated effect of wound healing.
Investigation into the mechanisms showed that IL-22 receptor, IL-22Rα1, was downregulated in the presence of nicotine as determined by q-PCR and flow cytometry.
We also investigated the effect of nicotine on IL-22 production by T cells.
Results indicate that nicotine inhibited the secretion of IL-22 from T cells in response to aryl hydrocarbon receptor (AHR) ligand, FICZ.
Altogether, the data suggests that nicotine negatively influences the IL-22-IL-22R axis.
This impairment may contribute to the nicotine-mediated detrimental effects on lung function.
American Psychological Association (APA)
Nguyen, Hannah My-Hanh& Torres, Jaclene Amber& Agrawal, Sudhanshu& Agrawal, Anshu. 2020. Nicotine Impairs the Response of Lung Epithelial Cells to IL-22. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191922
Modern Language Association (MLA)
Nguyen, Hannah My-Hanh…[et al.]. Nicotine Impairs the Response of Lung Epithelial Cells to IL-22. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1191922
American Medical Association (AMA)
Nguyen, Hannah My-Hanh& Torres, Jaclene Amber& Agrawal, Sudhanshu& Agrawal, Anshu. Nicotine Impairs the Response of Lung Epithelial Cells to IL-22. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1191922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191922