I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis
Joint Authors
Zhao, Yu
Wang, Jingwen
Zhang, Min
Li, Peng
Qi, Shuhong
Lin, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Regulatory dendritic cells (DCreg) have been reported to be a negative regulator in the immune response.
These cells are widely distributed in the liver, spleen, and lung.
However, the status and function of DCreg in the eyes and disease are still not very clear.
Herein, we found that the number of I-alowCD11bhigh DC increased in the eye and spleen at the recovery stage of experimental autoimmune uveitis (EAU), which is a mouse model for autoimmune uveitis.
These cells expressed lower levels of CD80, CD86, and CD54 than the mature DCs and expressed interleukin 10 (IL-10), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor beta (TGF-β) as well.
Moreover, these DCreg can regulate the development of EAU by promoting CD4+CD25+Foxp3+ regulatory T cells.
The increased interferon-gamma (IFN-γ) in the aqueous humor of EAU participates in inducing DCreg to alleviate the symptom of EAU.
Furthermore, DCreg was found to exist in the eyes of normal mice.
Aqueous humor, containing a certain concentration of IL-10, TGF-β, prostaglandin E2 (PGE2), IDO, and nitric oxide (NO), induced the tolerance of DCreg in normal eyes.
It can be concluded that DCreg exists in the eyes and plays a protective role in inflamed eyes.
These DCreg induced by IFN-γ might be used as a strategy to develop therapy for EAU management.
American Psychological Association (APA)
Zhao, Yu& Wang, Jingwen& Zhang, Min& Li, Peng& Qi, Shuhong& Lin, Wei. 2020. I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1191937
Modern Language Association (MLA)
Zhao, Yu…[et al.]. I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis. Mediators of Inflammation No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1191937
American Medical Association (AMA)
Zhao, Yu& Wang, Jingwen& Zhang, Min& Li, Peng& Qi, Shuhong& Lin, Wei. I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1191937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191937