Male Sex is an Inherent Risk Factor for Basal Cell Carcinoma

Abstract EN

Basal cell carcinoma (BCC) is more frequent among females <40 years old; however, it affects preferentially older males (>60 years old).

In order to contribute to the study of the still largely unknown mechanisms that underlie this peculiar sex-dependent shift, we compared the kinetics of the increase of the age-specific BCC incidence rates (R) as a function of age in males and females.

Studies reporting sex-stratified R were found using a PubMed search and male to female age-specific incidence rate ratios (RR) were calculated for each age-class as reported in each study and assigned to the mean of the corresponding age periods.

Trends in age were assessed with Kendall’s τ test and relationships between two variables by inverse variance method-weighed Loess and linear regression analysis.