High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice
Joint Authors
Lu, Bo
Yuan, Hui
Zhai, Xiaojie
Li, Xiaoyu
Qin, Jinling
Chen, Junping
Meng, Bo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients.
Neuroinflammation has been closely associated with the development of POCD.
While the contribution of pneumoperitoneum to the systemic inflammation has been well documented, the effect of pneumoperitoneal pressure on neuroinflammation and postoperative cognitive function remains unclear.
In this study, we showed that high-pressure pneumoperitoneum promoted the postoperative neuroinflammation and microglial activation in the hippocampus and aggravated the postoperative cognitive impairment in aged mice.
These results support the requirement to implement interventions with lower intra-abdominal pressure, which allows for adequate exposure of the operative field rather than a routine pressure.
American Psychological Association (APA)
Lu, Bo& Yuan, Hui& Zhai, Xiaojie& Li, Xiaoyu& Qin, Jinling& Chen, Junping…[et al.]. 2020. High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191947
Modern Language Association (MLA)
Lu, Bo…[et al.]. High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice. Mediators of Inflammation No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1191947
American Medical Association (AMA)
Lu, Bo& Yuan, Hui& Zhai, Xiaojie& Li, Xiaoyu& Qin, Jinling& Chen, Junping…[et al.]. High-Pressure Pneumoperitoneum Aggravates Surgery-Induced Neuroinflammation and Cognitive Dysfunction in Aged Mice. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1191947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191947