Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis
Joint Authors
Tai, Huiyu
Zhu, Zhiyun
Mei, Haifeng
Sun, Wenbin
Zhang, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
This study is aimed at investigating whether albumin-to-fibrinogen ratio (AFR) could independently predict the prognosis in patients with peritonitis-induced sepsis.
Methods.
A total of 246 eligible patients who were scheduled to undergo surgical treatment for peritonitis-induced sepsis were enrolled in this study.
The primary observational endpoint was 28-day hospital mortality.
Cox proportional hazards regression analysis with the Wald test was performed to identify prognostic factors for 28-day mortality in septic patients.
Receiver operating characteristic (ROC) and Kaplan-Meier curve analyses were carried out to evaluate the association of baseline AFR and prognosis in septic patients.
Results.
Of all the cohort study participants, there were 59 nonsurvivors with a 28-day mortality of 24.0% (59/246).
Baseline AFR (hazard ratio (HR): 0.67, 95% confidence interval (CI): 0.42–0.93, P=0.018) and the presence of septic shock (HR: 2.43, 95% CI: 1.42–3.91, P=0.021) were two independent prognostic factors for 28-day mortality in patients with peritonitis-induced sepsis by multivariate Cox analysis.
Baseline AFR was a significant predictor for 28-day mortality with an area under the curve (AUC) of 0.751, a cut-off value of 8.85, a sensitivity of 66.10%, and a specificity of 70.05%, respectively (95% CI: 0.688–0.813, P<0.001).
A low baseline AFR level (≤8.85) was significantly associated with a lower overall survival rate in septic patients by Kaplan-Meier curve analysis with log-rank test (P=0.004).
Conclusions.
This study indicates that AFR independently predicts 28-day mortality in patients with peritonitis-induced sepsis.
American Psychological Association (APA)
Tai, Huiyu& Zhu, Zhiyun& Mei, Haifeng& Sun, Wenbin& Zhang, Wei. 2020. Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191962
Modern Language Association (MLA)
Tai, Huiyu…[et al.]. Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis. Mediators of Inflammation No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1191962
American Medical Association (AMA)
Tai, Huiyu& Zhu, Zhiyun& Mei, Haifeng& Sun, Wenbin& Zhang, Wei. Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1191962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191962