Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse
Joint Authors
Rolot, Marion
Dewals, Benjamin G.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Macrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues.
Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13.
Alternative activation of macrophages by IL-4 in vitro was described as an opposite phenotype of classically activated macrophages, but the in vivo reality is much more complex.
Their exact activation state as well as the role of these cells and associated molecules in type 2 immune responses remains to be fully understood.
We can take advantage of a variety of helminth models available, each of which have their own feature including life cycle, site of infection, or pathological mechanisms influencing macrophage biology.
Here, we reviewed the recent advances from the laboratory mouse about macrophage origin, polarization, activation, and effector functions during parasitic helminth infection.
American Psychological Association (APA)
Rolot, Marion& Dewals, Benjamin G.. 2018. Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1191972
Modern Language Association (MLA)
Rolot, Marion& Dewals, Benjamin G.. Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse. Journal of Immunology Research No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1191972
American Medical Association (AMA)
Rolot, Marion& Dewals, Benjamin G.. Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1191972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191972