Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment
Joint Authors
Racanelli, Vito
Vacca, Angelo
Cicco, Sebastiano
Cicco, Gerolamo
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-16
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
COVID-19 is a pandemic disease caused by the new coronavirus SARS-CoV-2 that mostly affects the respiratory system.
The consequent inflammation is not able to clear viruses.
The persistent excessive inflammatory response can build up a clinical picture that is very difficult to manage and potentially fatal.
Modulating the immune response plays a key role in fighting the disease.
One of the main defence systems is the activation of neutrophils that release neutrophil extracellular traps (NETs) under the stimulus of autophagy.
Various molecules can induce NETosis and autophagy; some potent activators are damage-associated molecular patterns (DAMPs) and, in particular, the high-mobility group box 1 (HMGB1).
This molecule is released by damaged lung cells and can induce a robust innate immunity response.
The increase in HMGB1 and NETosis could lead to sustained inflammation due to SARS-CoV-2 infection.
Therefore, blocking these molecules might be useful in COVID-19 treatment and should be further studied in the context of targeted therapy.
American Psychological Association (APA)
Cicco, Sebastiano& Cicco, Gerolamo& Racanelli, Vito& Vacca, Angelo. 2020. Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-25.
https://search.emarefa.net/detail/BIM-1191978
Modern Language Association (MLA)
Cicco, Sebastiano…[et al.]. Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment. Mediators of Inflammation No. 2020 (2020), pp.1-25.
https://search.emarefa.net/detail/BIM-1191978
American Medical Association (AMA)
Cicco, Sebastiano& Cicco, Gerolamo& Racanelli, Vito& Vacca, Angelo. Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-25.
https://search.emarefa.net/detail/BIM-1191978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191978