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Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides
Joint Authors
Zhu, Junfeng
Yang, Fangli
Yue, Dan
Lu, Changlong
Sun, Xun
Wei, Bing
Zhang, Ran
Zhai, Jingbo
Liu, Xiaoyi
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Ganoderma lucidum polysaccharides (GLP) has anti-inflammatory and immunomodulatory effects.
Dysregulated immune responses are involved in the pathogenesis of dextran sulfate sodium (DSS)-induced colitis.
The aim of this study was to assess the therapeutic potential of GLP to alleviate DSS-induced colitis.
Methods.
The mice were administered with GLP by intragastric gavage daily for two weeks prior to the DSS treatment.
Mice were orally administered with 2.5% DSS dissolved in drinking water with GLP or water treatment for 6 days.
The mice were killed on day 7 after induction of colitis.
Survival rates, body weight loss, colon lengths, histological changes, and disease activity index scores (DAI) were evaluated.
Results.
GLP significantly improved survival rates, colon length shortening, body weight loss, histopathological score, and DAI scores in mice with DSS-induced colitis.
GLP markedly suppressed the secretions of TNF-α, IL-1β, IL-6, IL-17A, and IL-4 and significantly affected populations of Th17 cells, B cells, NK cells, and NKT cells in the lamina propria lymphocytes.
Conclusions.
GLP prevented inflammation, maintained intestinal homeostasis, and regulated the intestinal immunological barrier functions in mice with DSS-induced colitis.
American Psychological Association (APA)
Wei, Bing& Zhang, Ran& Zhai, Jingbo& Zhu, Junfeng& Yang, Fangli& Yue, Dan…[et al.]. 2018. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1191994
Modern Language Association (MLA)
Wei, Bing…[et al.]. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1191994
American Medical Association (AMA)
Wei, Bing& Zhang, Ran& Zhai, Jingbo& Zhu, Junfeng& Yang, Fangli& Yue, Dan…[et al.]. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1191994
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1191994