Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers
Joint Authors
Freitas, Antonio Carlos de
de Melo, Cristiane Moutinho Lagos
Venuti, Aldo
Barros, Marconi Rego
de Oliveira, Talita Helena Araújo
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers.
This virus is able to interrupt the initial events of the immune response, including the expression of Toll-like receptors (TLRs), cytokines, and inflammation.
Both TLRs and cytokines play a central role in HPV recognition, cell maturation and differentiation as well as immune signalling.
Therefore, the imbalance of this sensitive control of the immune response is a key factor for developing immunotherapies, which strengthen the host immune system to accomplish an efficient defence against HPV and HPV-infected cells.
Based on this, the review is aimed at exposing the HPV immune evasion mechanisms involving TLRs and cytokines and at discussing existing and potential immunotherapeutic TLR- and cytokine-related tools.
American Psychological Association (APA)
Barros, Marconi Rego& de Oliveira, Talita Helena Araújo& de Melo, Cristiane Moutinho Lagos& Venuti, Aldo& Freitas, Antonio Carlos de. 2018. Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1192005
Modern Language Association (MLA)
Barros, Marconi Rego…[et al.]. Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers. Journal of Immunology Research No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1192005
American Medical Association (AMA)
Barros, Marconi Rego& de Oliveira, Talita Helena Araújo& de Melo, Cristiane Moutinho Lagos& Venuti, Aldo& Freitas, Antonio Carlos de. Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1192005
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192005