Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat
Joint Authors
Lu, Cheng
He, Xiaojuan
Fan, Danping
Zheng, Kang
Luo, Hui
Qiu, Xuemei
Liu, Xue
Guo, Qingqing
Shen, Jiawen
Zhang, Ge
Lu, Ai-ping
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS).
There is still lack of commercially viable treatment currently.
Pien Tze Huang (PZH), a traditional Chinese medicine, has been proved to have anti-inflammatory, neuroprotective, and immunoregulatory effects.
This study investigated the possible therapeutic effects of PZH on experimental autoimmune encephalomyelitis (EAE) rats, a classic animal model of MS.
Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH.
Clinical symptoms, organ coefficient, histopathological features, levels of proinflammatory cytokines, and chemokines as well as MBP and Olig2 were analyzed.
The results indicated that PZH ameliorated the clinical severity of EAE rats.
It also remarkably reduced inflammatory cell infiltration in the CNS of EAE rats.
Furthermore, the levels of IL-17A, IL-23, CCL3, and CCL5 in serum and the CNS were significantly decreased; the p-P65 and p-STAT3 levels were also downregulated in the CNS, while MBP and Olig2 in the CNS of EAE rats had a distinct improvement after PZH treatment.
In addition, PZH has no obvious toxicity at the concentration of 0.486 g/kg/d.
This study demonstrated that PZH could be used to treat MS.
American Psychological Association (APA)
Qiu, Xuemei& Luo, Hui& Liu, Xue& Guo, Qingqing& Zheng, Kang& Fan, Danping…[et al.]. 2018. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192009
Modern Language Association (MLA)
Qiu, Xuemei…[et al.]. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192009
American Medical Association (AMA)
Qiu, Xuemei& Luo, Hui& Liu, Xue& Guo, Qingqing& Zheng, Kang& Fan, Danping…[et al.]. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192009