Diagnostic and Prognostic Value of IL-6 and sTREM-1 in SIRS and Sepsis in Children

Abstract EN

Purpose.

The aim of this study was to evaluate the diagnostic and prognostic value of IL-6 and sTREM-1 in the course of SIRS and sepsis in children with reference to routinely used CRP and PCT.

Methods.

A prospective study included 180 patients at the ages from 2 months to 18 years hospitalized due to fever from November 2015 to January 2017.

Forty-nine children without fever hospitalized due to noninfectious causes formed the control group.

IL-6 and sTREM-1 serum concentrations were assessed with the enzyme-linked immunosorbent assay method.

Results.

The mean serum concentrations of all the analyzed biomarkers were statistically significantly higher in the study group compared to the control group.

Mean IL-6, sTREM-1, and PCT serum concentrations were statistically significantly higher in the group of patients with SIRS/sepsis compared to the group of feverish patients without diagnosed SIRS (N-SIRS).

Based on the ROC curve analysis, it was shown that of all the biomarkers tested, only two—IL-6 and procalcitonin—had potential usefulness in the diagnosis of SIRS/sepsis in children with fever.

Conclusion.

Elevated levels of IL-6 and PCT are important risk factors for the development of SIRS/sepsis in children with fever.

It seems that elevated IL-6 baseline serum level may predict a more severe course of febrile illness in children, because based on the ROC curve analysis, it was found that IL-6 is a statistically significant prognostic marker of prolonged fever≥3 days and prolonged hospitalization>10 days.

The assessment of the usefulness of sTREM-1 in the diagnosis of SIRS/sepsis in feverish children requires further research.