The Role of Inflammation in the Pathogenesis of Osteoarthritis
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-03
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
A joint is the point of connection between two bones in our body.
Inflammation of the joint leads to several diseases, including osteoarthritis, which is the concern of this review.
Osteoarthritis is a common chronic debilitating joint disease mainly affecting the elderly.
Several studies showed that inflammation triggered by factors like biomechanical stress is involved in the development of osteoarthritis.
This stimulates the release of early-stage inflammatory cytokines like interleukin-1 beta (IL-1β), which in turn induces the activation of signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and mitogen-activated protein kinase (MAPK).
These events, in turn, generate more inflammatory molecules.
Subsequently, collagenase like matrix metalloproteinases-13 (MMP-13) will degrade the extracellular matrix.
As a result, anatomical and physiological functions of the joint are altered.
This review is aimed at summarizing the previous studies highlighting the involvement of inflammation in the pathogenesis of osteoarthritis.
American Psychological Association (APA)
Chow, Yoke Yue& Chin, Kok-Yong. 2020. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1192057
Modern Language Association (MLA)
Chow, Yoke Yue& Chin, Kok-Yong. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators of Inflammation No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1192057
American Medical Association (AMA)
Chow, Yoke Yue& Chin, Kok-Yong. The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1192057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192057