![](/images/graphics-bg.png)
Proinflammatory Effects of Ubiquitin-Specific Protease 5 (USP5) in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Joint Authors
Luo, Xiao-Bo
Xi, Jian-Cheng
Liu, Zhen
Long, Yu
Li, Li-tao
Luo, Zhan-Peng
Liu, Dao-Hong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a worldwide chronic autoimmune inflammatory disease which is affecting approximately 1% of the total population.
It is characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS) and increased production of proinflammatory cytokines.
In the current study, we were aiming to investigate the role of ubiquitin-specific protease 5 (USP5) in the inflammatory process in RA-FLS.
Expression of USP5 was found upregulated in RA-FLS compared with that in osteoarthritis- (OA-) FLS, and IL-1β stimulation increased USP5 expression in a time-dependent manner.
Furthermore, we found that USP5 overexpression significantly aggravated proinflammatory cytokine production and related nuclear factor κB (NF-κB) signaling activation.
Consistently, silencing of USP5 decreased the release of cytokines and inhibited the activation of NF-κB.
In addition, USP5 was found to interact with tumor necrosis factor receptor-associated factor 6 (TRAF6) and remove its K48-linked polyubiquitination chains therefore stabilizing TRAF6.
Our data showed that a USP5-positive cell regulates inflammatory processes in RA-FLS and suggested USP5 as a potential target for RA treatment.
American Psychological Association (APA)
Luo, Xiao-Bo& Xi, Jian-Cheng& Liu, Zhen& Long, Yu& Li, Li-tao& Luo, Zhan-Peng…[et al.]. 2020. Proinflammatory Effects of Ubiquitin-Specific Protease 5 (USP5) in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1192063
Modern Language Association (MLA)
Luo, Xiao-Bo…[et al.]. Proinflammatory Effects of Ubiquitin-Specific Protease 5 (USP5) in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1192063
American Medical Association (AMA)
Luo, Xiao-Bo& Xi, Jian-Cheng& Liu, Zhen& Long, Yu& Li, Li-tao& Luo, Zhan-Peng…[et al.]. Proinflammatory Effects of Ubiquitin-Specific Protease 5 (USP5) in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1192063
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192063