High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury
Joint Authors
Chen, Xiangmei
Hong, Quan
Wu, Di
Cai, Guangyan
Fu, Bo
Wang, Liyuan
Huang, Zhiyong
Feng, Zhe
Cui, Shaoyuan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Renin angiotensin (Ang) system (RAS) activation in metabolic syndrome (MS) patients is associated with elevated uric acid (UA) levels, resulting in endothelial system dysfunction.
Our previous study demonstrated that excessive UA could cause endothelial injury through the aldose reductase (AR) pathway.
This study is the first to show that a high concentration of Ang II in human umbilical vein endothelial cells (HUVECs) increases reactive oxygen species (ROS) components, including O2⋅- and H2O2, and further aggravates endothelial system injury induced by high UA (HUA).
In a MS/hyperuricemia model, nitric oxide (NO) production was decreased, followed by a decrease in total antioxidant capacity (TAC), and the concentration of the endothelial injury marker von Willebrand factor (vWF) in the serum was increased.
Treatment with catalase and polyethylene glycol covalently linked to superoxide dismutase (PEG-SOD) to individually remove H2O2 and O2⋅- or treatment with the AR inhibitor epalrestat decreased ROS and H2O2, increased NO levels and TAC, and reduced vWF release.
Taken together, these data indicate that HUA and Ang II act additively to cause endothelial dysfunction via oxidative stress, and specific elimination of O2⋅- and H2O2 improves endothelial function.
We provide theoretical evidence to prevent or delay endothelial injury caused by metabolic diseases.
American Psychological Association (APA)
Hong, Quan& Wang, Liyuan& Huang, Zhiyong& Feng, Zhe& Cui, Shaoyuan& Fu, Bo…[et al.]. 2020. High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192074
Modern Language Association (MLA)
Hong, Quan…[et al.]. High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1192074
American Medical Association (AMA)
Hong, Quan& Wang, Liyuan& Huang, Zhiyong& Feng, Zhe& Cui, Shaoyuan& Fu, Bo…[et al.]. High Concentrations of Uric Acid and Angiotensin II Act Additively to Produce Endothelial Injury. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192074