Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4JNKERKNF-κB Pathway

Joint Authors

Xiang, Yan
Zhang, Yulu
Long, Yu
Liu, Songyu
Wan, Jinyan
Yang, Qiyue
Cui, Mingquan
Ci, Zhimin
Li, Nan
Peng, Wei

Source

Mediators of Inflammation

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-11-11

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are challenging diseases with the high mortality in a clinical setting.

Baicalin (BA) is the main effective constituent isolated from the Chinese medical herb Scutellaria baicalensis Georgi, and studies have proved that it has a protective effect on ALI induced by lipopolysaccharide (LPS) due to the anti-inflammatory efficacy.

However, BA has low solubility which may limit its clinical application.

Hence, we prepared a novel drug delivery system—Baicalin liposome (BA-LP) in previous research—which can improve some physical properties of BA.

Therefore, we aimed to explore the effect of BA-LP on ALI mice induced by LPS.

In pharmacokinetics study, the values of t1/2 and AUC0-t in the BA-LP group were significantly higher than that of the BA group in normal mice, indicating that BA-LP could prolong the duration time in vivo of BA.

The BA-LP group also showed a higher concentration in lung tissues than the BA group.

Pharmacodynamics studies showed that BA-LP had a better effect than the BA group at the same dosage on reducing the W/D ratio, alleviating the lung injury score, and decreasing the proinflammatory factors (TNF-α, IL-1β) and total proteins in bronchoalveolar lavage fluids (BALF).

In addition, the therapeutic effects of BA-LP showed a dose-dependent manner.

Western blot analysis indicated that the anti-inflammatory action of BA could be attributed to the inhibition of the TLR4-NFκBp65 and JNK-ERK signaling pathways.

These results suggest that BA-LP could be a valuable therapeutic candidate in the treatment of ALI.

American Psychological Association (APA)

Long, Yu& Xiang, Yan& Liu, Songyu& Zhang, Yulu& Wan, Jinyan& Yang, Qiyue…[et al.]. 2020. Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4JNKERKNF-κB Pathway. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192078

Modern Language Association (MLA)

Long, Yu…[et al.]. Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4JNKERKNF-κB Pathway. Mediators of Inflammation No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1192078

American Medical Association (AMA)

Long, Yu& Xiang, Yan& Liu, Songyu& Zhang, Yulu& Wan, Jinyan& Yang, Qiyue…[et al.]. Baicalin Liposome Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice via Inhibiting TLR4JNKERKNF-κB Pathway. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1192078

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192078