Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice
Joint Authors
Ma, Fangli
Hu, Minghua
Deng, Xiangliang
Luo, Shuang
Luo, Xia
Wang, Yuanyuan
Zhou, Lian
Lai, Xiao-Ping
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal Lycium barbarum.
Previous studies had demonstrated that LBP could inhibit tumor growth and enhance the immunity in mice.
However, the effect of LBP on systemic and local immune responses in vivo, especially on phenotypic and functional changes of T cells, is still largely unknown.
In the present study, we investigated the effects of LBP on systemic and local T cell-dependent antitumor immune responses in H22 tumor-bearing mice.
The results showed that LBP could inhibit the solid tumor growth in mice, but showed little effect on the body weight or spleen index.
Furthermore, LBP could maintain high levels of T cells in peripheral blood (PB), tumor draining lymph node (TDLN), and tumor tissue, prevent the increase of Tregs while promote infiltration of CD8+ T cells in tumor tissue, inhibit the production of TGF-β1 and IL-10 in serum, decrease the exhaustion phenotype of T cells, and maintain cytotoxicity of lymphocytes.
Taken together, our results demonstrated that LBP simultaneously induced systemic and local immune responses in H22 tumor-bearing mice by alleviating immunosuppression and maintaining antitumor immune responses in mice.
American Psychological Association (APA)
Deng, Xiangliang& Luo, Shuang& Luo, Xia& Hu, Minghua& Ma, Fangli& Wang, Yuanyuan…[et al.]. 2018. Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192080
Modern Language Association (MLA)
Deng, Xiangliang…[et al.]. Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1192080
American Medical Association (AMA)
Deng, Xiangliang& Luo, Shuang& Luo, Xia& Hu, Minghua& Ma, Fangli& Wang, Yuanyuan…[et al.]. Polysaccharides from Chinese Herbal Lycium barbarum Induced Systemic and Local Immune Responses in H22 Tumor-Bearing Mice. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192080