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Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System
Joint Authors
Delafontaine, Marie
Villas-Boas, Isadora Maria
Pidde, Giselle
Mathieu, Laurence
Blomet, Joël
Tambourgi, Denise Vilarinho
van den Berg, Carmen Wilma
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Bothrops lanceolatus snake venom causes systemic thrombotic syndrome but also local inflammation involving extensive oedema, pain, and haemorrhage.
Systemic thrombotic syndrome may lead to fatal pulmonary embolism and myocardial and cerebral infarction.
Here, we investigated the ability of B.
lanceolatus venom to activate the Complement system (C) in order to improve the understanding of venom-induced local inflammation.
Data presented show that B.
lanceolatus venom is able to activate all C-pathways.
In human serum, the venom strongly induced the generation of anaphylatoxins, such as C5a and C4a, and the Terminal Complement complex.
The venom also induced cleavage of purified human components C3, C4, and C5, with the production of biologically active C5a.
Furthermore, the venom enzymatically inactivated the soluble C-regulator and the C1-inhibitor (C1-INH), and significantly increased the expression of bound C-regulators, such as MCP and CD59, on the endothelial cell membrane.
Our observations that B.
lanceolatus venom activates the three Complement activation pathways, resulting in anaphylatoxins generation, may suggest that this could play an important role in local inflammatory reaction and systemic thrombosis caused by the venom.
Inactivation of C1-INH, which is also an important inhibitor of several coagulation proteins, may also contribute to inflammation and thrombosis.
Thus, further in vivo studies may support the idea that therapeutic management of systemic B.
lanceolatus envenomation could include the use of Complement inhibitors as adjunct therapy.
American Psychological Association (APA)
Delafontaine, Marie& Villas-Boas, Isadora Maria& Pidde, Giselle& van den Berg, Carmen Wilma& Mathieu, Laurence& Blomet, Joël…[et al.]. 2018. Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192093
Modern Language Association (MLA)
Delafontaine, Marie…[et al.]. Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1192093
American Medical Association (AMA)
Delafontaine, Marie& Villas-Boas, Isadora Maria& Pidde, Giselle& van den Berg, Carmen Wilma& Mathieu, Laurence& Blomet, Joël…[et al.]. Venom from Bothrops lanceolatus, a Snake Species Native to Martinique, Potently Activates the Complement System. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192093
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192093