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Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice
Joint Authors
Schülke, Stefan
Vieths, Stefan
Scheurer, Stephan
Wangorsch, Andrea
Toda, Masako
Rodriguez, Maria J.
Gomez, Francisca
Torres, Maria J.
Mayorga, Cristobalina
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
The use of hypoallergenic derivatives is considered beneficial to promote the safety and efficacy of allergen-specific immunotherapy.
We aimed to assess the efficacy of reduced and alkylated (R/A) Pru p 3, a hypoallergenic folding variant of the major peach allergen, in subcutaneous immunotherapy (SCIT) using a murine model of peach allergy.
Methods and Results.
After sensitization with Pru p 3, BALB/c mice received SCIT with Pru p 3 or R/A Pru p 3 and were challenged with Pru p 3.
SCIT with Pru p 3, but not with R/A Pru p 3, suppressed anaphylaxis upon the challenge significantly.
SCIT with Pru p 3 did not suppress Pru p 3-specific IgE and IgG1 production, but enhanced IgG2a production.
In contrast, SCIT with R/A Pru p 3 suppressed IgE and IgG1 production, but enhanced IgG2a production only moderately.
The therapeutic efficacy of SCIT with Pru p 3 was associated with induction of IL-10 and IFN-γ.
Conclusion.
Hypoallergenic folding variant of Pru p 3 is not likely an efficacious therapeutic component in SCIT of peach allergy.
The lower efficacy of R/A Pru p 3 might be attributed to poor antigenicity and/or weak stability due to its unfolded conformation.
American Psychological Association (APA)
Rodriguez, Maria J.& Wangorsch, Andrea& Gomez, Francisca& Schülke, Stefan& Torres, Maria J.& Vieths, Stefan…[et al.]. 2018. Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192096
Modern Language Association (MLA)
Rodriguez, Maria J.…[et al.]. Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192096
American Medical Association (AMA)
Rodriguez, Maria J.& Wangorsch, Andrea& Gomez, Francisca& Schülke, Stefan& Torres, Maria J.& Vieths, Stefan…[et al.]. Immunotherapy with Native Molecule rather than Hypoallergenic Variant of Pru p 3, the Major Peach Allergen, Shows Beneficial Effects in Mice. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192096
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192096