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Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy
Joint Authors
Chen, Chao
Tan, Lirong
Zhu, Wu
Lei, Li
Kuang, Yehong
Liu, Panpan
Li, Jie
Chen, Xiang
Peng, Cong
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Psoriasis is a common immune-mediated, chronic inflammatory genetic-related disease that affects patients’ quality of life.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of progenitor and immature myeloid cells which are expanded in psoriatic skin lesions and peripheral blood.
However, the role of MDSCs in the pathogenesis of psoriasis remains unclear.
Here, we confirmed that the accumulation of human MDSCs is remarkably increased in skin lesions of psoriasis patients by flow cytometry.
Depleting MDSCs by Gemcitabine significantly suppresses IMQ-induced psoriatic inflammation and epidermal thickening as well as Th17 and Treg cell accumulation.
Moreover, through the RNA-Seq technique, we validated some differentially expressed genes on CD4+ T-cells of IMQ-induced-MDSC-depleted mice such as IL-21 and Timd2, which are involved in Th17-cell differentiation or T-cell activation.
Interestingly, neutralizing IL-21R by antibody reduces IMQ-induced epidermal thickening through downregulating the infiltration of MDSCs and Th17 cells.
Our data suggest that targeting myeloid-derived suppressor cells is a novel strategy for antipsoriasis therapy.
IL-21 may be a potential therapeutic target in psoriasis.
American Psychological Association (APA)
Chen, Chao& Tan, Lirong& Zhu, Wu& Lei, Li& Kuang, Yehong& Liu, Panpan…[et al.]. 2020. Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1192103
Modern Language Association (MLA)
Chen, Chao…[et al.]. Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy. Mediators of Inflammation No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1192103
American Medical Association (AMA)
Chen, Chao& Tan, Lirong& Zhu, Wu& Lei, Li& Kuang, Yehong& Liu, Panpan…[et al.]. Targeting Myeloid-Derived Suppressor Cells Is a Novel Strategy for Anti-Psoriasis Therapy. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1192103
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192103