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Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response
Joint Authors
Choi, Seunga
Choi, Han-Gyu
Shin, Ki-Won
Back, Yong Woo
Park, Hye-Soo
Lee, Jae Hwi
Kim, Hwa-Jung
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The attenuated vaccine Mycobacterium bovis BCG (Bacille Calmette Guerin) has limited protective efficacy against TB.
The development of more effective TB vaccines has focused on the mycobacterial antigens that cause strong T helper 1 (Th1) responses.
Mtb protein Rv3841 (bacterioferritin B; BfrB) is known to play a crucial role in the growth of Mtb.
Nonetheless, it is unclear whether Rv3841 can induce protective immunity against Mtb.
Here, we studied the action of Rv3841 in maturation of dendritic cells (DCs) and its engagement in the development of T-cell immunity.
We found that Rv3841 functionally activated DCs by upregulating costimulatory molecules and increased secretion of proinflammatory cytokines.
Activation of DCs by Rv3841 was mediated by Toll-like receptor 4 (TLR4), followed by triggering of mitogen-activated protein kinase and nuclear factor-κB signaling pathways.
In addition, Rv3841-matured DCs effectively proliferated and polarized Th1 immune response of naïve CD4+ and CD8+ T-cells.
Moreover, Rv3841 specifically caused the expansion of CD4+CD44highCD62Llow T-cells from Mtb-infected mice; besides, the T-cells activated by Rv3841-matured DCs inhibited intracellular mycobacterial growth.
Our data suggest that Rv3841 induces DC maturation and protective immune responses, a finding that may provide candidate of effective TB vaccines.
American Psychological Association (APA)
Choi, Seunga& Choi, Han-Gyu& Shin, Ki-Won& Back, Yong Woo& Park, Hye-Soo& Lee, Jae Hwi…[et al.]. 2018. Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192111
Modern Language Association (MLA)
Choi, Seunga…[et al.]. Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response. Journal of Immunology Research No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1192111
American Medical Association (AMA)
Choi, Seunga& Choi, Han-Gyu& Shin, Ki-Won& Back, Yong Woo& Park, Hye-Soo& Lee, Jae Hwi…[et al.]. Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1192111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192111