The Imbalance between Foxp3+Tregs and Th1Th17Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis
Joint Authors
Ma, Liang
Liwen, Zhang
Yun, Zhuang
Yanbo, Ding
Jianping, Chen
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study is aimed at examining the potential role of regulatory T- (Treg-) Th1-Th17-Th22 cells in the pathogenic process of autoimmune hepatitis (AIH).
The numbers of Foxp3+Tregs and Th1, Th17, and Th22 cells were measured in 32 AIH patients using flow cytometry.
Moreover, a murine model of experimental autoimmune hepatitis (EAH) was also established and used to investigate the function of Treg-Th1-Th17-Th22 cells in disease progression.
AIH patients undergoing an active state had significantly decreased numbers of CD3+CD4+CD25+Foxp3+Tregs and increased numbers of CD3+CD4+CD25−Foxp3+T, CD3+CD4+IFN-γ+Th1, CD3+CD4+IL-17+Th17, and CD3+CD4+IL-2+Th22 cells as well as higher levels of Th1/Th17/Th22-type cytokines compared to AIH patients in remission and HC.
Additionally, the numbers of CD3+CD4+CD25+Foxp3+Tregs were negatively correlated with the numbers of Th1-Th17-Th22 cells.
Also, the serum levels of IL-17A and IL-22 were correlated positively with liver injury (ALT/AST), whereas the serum levels of IL-10 were correlated negatively with hypergammaglobulinaemia (IgG, IgM) in AIH patients.
Interestingly, the percentages of spleen Tregs, expression of Foxp3 mRNA, and liver IL-10 levels decreased, whereas the percentages of spleen Th1-Th17-Th22 cells, expression of T-bet/AHR/RORγt mRNA, and liver IFN-γ, IL-17, and IL-22 levels increased in the murine model of EAH.
Our findings demonstrated that an imbalance between Tregs and Th1-Th17-Th22 cells might contribute to the pathogenic process of AIH.
American Psychological Association (APA)
Ma, Liang& Liwen, Zhang& Yun, Zhuang& Yanbo, Ding& Jianping, Chen. 2018. The Imbalance between Foxp3+Tregs and Th1Th17Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192190
Modern Language Association (MLA)
Ma, Liang…[et al.]. The Imbalance between Foxp3+Tregs and Th1Th17Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1192190
American Medical Association (AMA)
Ma, Liang& Liwen, Zhang& Yun, Zhuang& Yanbo, Ding& Jianping, Chen. The Imbalance between Foxp3+Tregs and Th1Th17Th22 Cells in Patients with Newly Diagnosed Autoimmune Hepatitis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192190