Association of Lifestyle and Body Composition on Risk Factors of Cardiometabolic Diseases and Biomarkers in Female Adolescents

Abstract EN

Background.

Female adolescents are considered a risk group for cardiometabolic disease due to their lifestyle (LS).

Objective.

To evaluate the association between LS classes and body composition groups with cardiometabolic disease risk factors and pro- and anti-inflammatory biomarkers in female adolescents.

Methods.

This cross-sectional study was carried out with female adolescents aged 14 to 19 years, from Viçosa-MG, Brazil.

Latent class analysis assessed LS classes.

Kinanthropometric measurements were taken together with the body fat percentage (BF%), being analyzed by the Dual Energy X-ray Absorptiometry (DEXA) equipment.

Blood pressure and biochemical parameters were analyzed in the Health Division of the Federal University of Viçosa.

The pro- and anti-inflammatory biomarkers were analyzed using Luminex technology.

Associations with biomarkers were estimated by multiple linear regression.

Results.

405 female adolescents were evaluated.

The majority, 82.57%, 72.90%, and 65.31%, were classified as inactive by the number of steps, with high screen and cell phone time, respectively.

Furthermore, 41.55% did meet the minimum of 60 minutes of moderate-to-vigorous physical activity (MVPA) and 54.69% had high values of BF% (DEXA).

The “Sedentary & Inactive LS” class together with the high levels of weight and BF% were associated with increased levels of blood pressure, lipid profile, and uric acid.

It was also found that “Inactive & Sedentary LS”, high BF%, insulin resistance, and ultra-sensitive C-reactive protein were associated with the concentrations of proinflammatory biomarkers of tumor necrosis factor-α, interleukin-6, and leptin.

Conclusion.

We concluded that female adolescents with overweight/obese and high BF% presented higher values of anthropometric indicators, levels of blood pressure, concentration of uric acid and hs-CRP, and lower concentration of HDL.

Inactive and Sedentary lifestyle of these girls, along with excess body fat, insulin resistance, and higher concentrations of hs-CRP were associated with the higher concentration proinflammatory markers.