Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats
Joint Authors
Karim, Nurul
Tanvir, E. M.
Khalil, Md. Ibrahim
Alam, Nadia
Saha, Moumoni
Rumpa, Nur-E-Noushin
Hossen, Md. Sakib
Ali, Md. Yousuf
Hossan, Tareq
Paul, Sudip
Gan, Siew Hua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of this study was to investigate the antioxidant potentials, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandis L.
Osbeck) in rats.
Long Evans rats were divided into four groups of eight animals each.
The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21 days.
Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values.
There was no significant change in the body weight, percentage water content, and relative organ weight at any administered doses.
In addition, no significant alterations in the hematological parameters were also observed.
However, rats which received 1000 mg/kg dose had a significant reduction in some serum parameters, including alanine transaminase (15.29%), alkaline phosphatase (2.5%), lactate dehydrogenase (15.5%), γ-glutamyltransferase (20%), creatinine (14.47%), urea (18.50%), uric acid (27.14%), total cholesterol (5.78%), triglyceride (21.44%), low-density lipoprotein cholesterol (40.74%), glucose (2.48%), and all atherogenic indices including cardiac risk ratio (24.30%), Castelli’s risk index-2 (45.71%), atherogenic coefficient (42%), and atherogenic index of plasma (25%) compared to control.
In addition, the highest dose (1000 mg/kg) caused a significant increase in iron (12.07%) and high-density lipoprotein cholesterol (8.87%) levels.
Histopathological findings of the vital organs did not indicate any pathological changes indicating that pomelo is nontoxic, safe, and serves as an important source of natural antioxidants.
In addition, the fruit extract has the potential to ameliorate hepato- and nephrotoxicities and cardiovascular diseases as well as iron deficiency anemia.
American Psychological Association (APA)
Ali, Md. Yousuf& Rumpa, Nur-E-Noushin& Paul, Sudip& Hossen, Md. Sakib& Tanvir, E. M.& Hossan, Tareq…[et al.]. 2019. Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192201
Modern Language Association (MLA)
Ali, Md. Yousuf…[et al.]. Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats. Journal of Toxicology No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1192201
American Medical Association (AMA)
Ali, Md. Yousuf& Rumpa, Nur-E-Noushin& Paul, Sudip& Hossen, Md. Sakib& Tanvir, E. M.& Hossan, Tareq…[et al.]. Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192201