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Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies
Joint Authors
Deshmukh, Gajanan
Venkataramaiah, Suresh B.
Doreswamy, Chandrashekar M.
Umesh, Mohan C.
Subbanna, Rajesh B.
Pradhan, Bikram K.
Seekallu, Srinivas
Sekar, Rajan
Prabhu, Karthick
Sadagopan, Sathish
Arumugam, Shri Natrajan
Sharma, Satish
Gavara, Govindarajulu
Balaraman, Selvakumar
Sambasivam, Ganesh
Chandrappa, Ravindra K.
Flynn, Sarah
Shivarudraiah, Prasad
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-01
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
Coenzyme Q10 (CoQ10) is a lipid soluble, endogenous antioxidant present at highest levels in the heart followed by the kidney and liver.
The reduced CoQ10 ubiquinol is well known for its chemical instability and low bioavailability.
The present study was designed to synthesize ubiquinol acetate, which is more stable and biologically active, and further evaluate its safety and genotoxic potential.
Synthesized ubiquinol acetate showed better stability than that of ubiquinol at the end of 3 months.
In vitro genotoxicity studies (AMES test, in vitro micronucleus and chromosomal aberration) showed ubiquinol acetate as nongenotoxic with no clastogenic or aneugenic effects at high dose of 5000 and 62.5 μg/mL, respectively.
In subchronic toxicity study, ubiquinol acetate was administered orally to Sprague Dawley rats at 150, 300, and 600 mg/kg/day for 90 days.
No treatment related adverse effects were observed in males at 600 mg/kg/day; however, females showed treatment related increase in AST and ALT with small focal irregular white-yellow spots in liver on gross necropsy examination.
Histopathological evaluation revealed hepatocellular necrosis in high dose females which was considered as adverse.
Based on the results, the No-Observed-Adverse-Effect Level (NOAEL) of ubiquinol acetate in males and females was determined as 600 and 300 mg/kg/day, respectively.
American Psychological Association (APA)
Deshmukh, Gajanan& Venkataramaiah, Suresh B.& Doreswamy, Chandrashekar M.& Umesh, Mohan C.& Subbanna, Rajesh B.& Pradhan, Bikram K.…[et al.]. 2019. Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-25.
https://search.emarefa.net/detail/BIM-1192214
Modern Language Association (MLA)
Deshmukh, Gajanan…[et al.]. Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies. Journal of Toxicology No. 2019 (2019), pp.1-25.
https://search.emarefa.net/detail/BIM-1192214
American Medical Association (AMA)
Deshmukh, Gajanan& Venkataramaiah, Suresh B.& Doreswamy, Chandrashekar M.& Umesh, Mohan C.& Subbanna, Rajesh B.& Pradhan, Bikram K.…[et al.]. Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-25.
https://search.emarefa.net/detail/BIM-1192214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192214