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Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention
Joint Authors
Zhou, Jinying
Sheng, Zhaoxue
Liu, Chen
Zhou, Peng
Li, Jiannan
Chen, Runzhen
Song, Li
Zhao, Hanjun
Yan, Hongbing
Chen, Yi
Tan, Yu
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Inflammation poses dual effects after myocardial infarction, but robust evidence shows that high-sensitivity C-reactive protein (hsCRP), as an inflammatory marker, is constantly associated with worse outcomes.
This study is aimed at investigating the probable nonlinear association between postprocedural hsCRP and mortality in patients with acute coronary syndromes (ACS) treated by percutaneous coronary intervention (PCI).
Methods.
A total of 3940 consecutive ACS patients treated by PCI with postprocedural hsCRP measurements were retrospectively recruited.
Patients were stratified into 5 groups according to quintiles of hsCRP.
Cox regression with adjustments for multiple covariates was used for outcome analysis.
Restricted cubic spline (RCS) analysis was used to allow possible nonlinear associations.
The primary outcome was all-cause death.
Results.
During a median follow-up of 727 days, mortality occurred in 207 (5.3%) patients.
Adjusted hazard ratio (HR) was higher in the lowest (<2.26 mg/L, HR: 1.90, 95% confidence interval (CI): 1.08-3.33; P=0.025), second highest (10.16-12.56 mg/L, HR: 1.86, 95% CI: 1.09-3.16; P=0.023), and highest quintiles (≥12.56 mg/L, HR: 2.02, 95% CI: 1.21-3.36; P=0.007) of postprocedural hsCRP, compared to the second lowest quintile (2.26-4.85 mg/L).
RCS analysis depicted a J-shaped association between postprocedural hsCRP and mortality (P for nonlinearity=0.004).
Similar association was observed between hsCRP and cardiac death (P for nonlinearity=0.014), but not for noncardiac mortality (P for nonlinearity=0.228).
Conclusions.
Both low and high postprocedural hsCRP were associated with higher risk of death in ACS patients treated by PCI.
American Psychological Association (APA)
Chen, Runzhen& Liu, Chen& Zhou, Peng& Tan, Yu& Sheng, Zhaoxue& Li, Jiannan…[et al.]. 2020. Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1192215
Modern Language Association (MLA)
Chen, Runzhen…[et al.]. Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention. Mediators of Inflammation No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1192215
American Medical Association (AMA)
Chen, Runzhen& Liu, Chen& Zhou, Peng& Tan, Yu& Sheng, Zhaoxue& Li, Jiannan…[et al.]. Both Low and High Postprocedural hsCRP Associate with Increased Risk of Death in Acute Coronary Syndrome Patients Treated by Percutaneous Coronary Intervention. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1192215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192215