March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation
Joint Authors
Galbas, Tristan
Thibodeau, Jacques
Sabourin, Antoine
Simon, Leora
McGovern, Toby
Raymond, Maxime
Majdoubi, Abdelilah
Ishido, Satoshi
Martin, James G.
Kishta, Osama A.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases.
March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation.
Given the key roles of MHC class II and CD86 in T cell activation and to get further insights into the development of allergic inflammation, we asked whether March1 deficiency exacerbates or attenuates features of allergic asthma in mice.
Herein, we used an acute model of allergy to compare the asthmatic phenotype of March1-deficient and -sufficient mice immunized with ovalbumin (OVA) and later challenged by intranasal instillation of OVA in the lungs.
We found that eosinophilic inflammation in airways and lung tissue was similar between WT and March1−/− allergic mice, whereas neutrophilic inflammation was significant only in March1−/− mice.
Airway hyperresponsiveness as well as levels of IFN-γ, IL-13, IL-6, and IL-10 was lower in the lungs of asthmatic March1−/− mice compared to WT, whereas lung levels of TNF-α, IL-4, and IL-5 were not significantly different.
Interestingly, in the serum, levels of total and ova-specific IgE were reduced in March1-deficient mice as compared to WT mice.
Taken together, our results demonstrate a role of March1 E3 ubiquitin ligase in modulating allergic responses.
American Psychological Association (APA)
Kishta, Osama A.& Sabourin, Antoine& Simon, Leora& McGovern, Toby& Raymond, Maxime& Galbas, Tristan…[et al.]. 2018. March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1192222
Modern Language Association (MLA)
Kishta, Osama A.…[et al.]. March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation. Journal of Immunology Research No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1192222
American Medical Association (AMA)
Kishta, Osama A.& Sabourin, Antoine& Simon, Leora& McGovern, Toby& Raymond, Maxime& Galbas, Tristan…[et al.]. March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1192222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192222