A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin
Joint Authors
Clewell, Amy
Glávits, Róbert
Endres, John R.
Reddeman, Robin A.
Hirka, Gábor
Vértesi, Adél
Béres, Erzsébet
Szakonyiné, Ilona Pasics
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-01
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE).
No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames).
While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw).
A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day.
Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.
American Psychological Association (APA)
Reddeman, Robin A.& Glávits, Róbert& Endres, John R.& Clewell, Amy& Hirka, Gábor& Vértesi, Adél…[et al.]. 2019. A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192227
Modern Language Association (MLA)
Reddeman, Robin A.…[et al.]. A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin. Journal of Toxicology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1192227
American Medical Association (AMA)
Reddeman, Robin A.& Glávits, Róbert& Endres, John R.& Clewell, Amy& Hirka, Gábor& Vértesi, Adél…[et al.]. A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192227