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The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis
Joint Authors
Wei, Wei
Mei, Dan
Zhu, Yue
Zhang, Lingling
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein.
CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury.
CTHRC1 plays a pivotal role in some pathophysiological processes, including increasing bone mass, preventing myelination, and reversing collagen synthesis in many tumor cells.
The ascended expression of CTHRC1 is related to tumorigenesis, proliferation, invasion, and metastasis in various human malignancies, including gastric cancer, pancreatic cancer, hepatocellular carcinoma, keloid, breast cancer, colorectal cancer, epithelial ovarian cancer, esophageal squamous cell carcinoma, cervical cancer, non-small-cell lung carcinoma, and melanoma.
And molecules that regulate the expression of CTHRC1 include miRNAs, lncRNAs, WAIF1, and DPAGT1.
Many reports have pointed that CTHRC1 could exert different effects through several signaling pathways such as TGF-β, Wnt, integrin β/FAK, Src/FAK, MEK/ERK, PI3K/AKT/ERK, HIF-1α, and PKC-δ/ERK signaling pathways.
As a participant in tissue remodeling or immune response, CTHRC1 may promote early-stage cancer.
Several recent studies have identified CTHRC1 as an effectual prognostic biomarker for predicting tumor recurrence or metastasis.
It is worth noting that CTHRC1 has different cellular localization and mechanisms of action in different cells and different microenvironments.
In this article, we focus on the advances in the signaling pathways mediated by CTHRC1 in tumors.
American Psychological Association (APA)
Mei, Dan& Zhu, Yue& Zhang, Lingling& Wei, Wei. 2020. The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis. Mediators of Inflammation،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1192234
Modern Language Association (MLA)
Mei, Dan…[et al.]. The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis. Mediators of Inflammation No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1192234
American Medical Association (AMA)
Mei, Dan& Zhu, Yue& Zhang, Lingling& Wei, Wei. The Role of CTHRC1 in Regulation of Multiple Signaling and Tumor Progression and Metastasis. Mediators of Inflammation. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1192234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192234