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Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study
Joint Authors
Laurent, Sophie
Colet, Jean-Marie
Valentini, Xavier
Rugira, Pascaline
Frau, Annica
Tagliatti, Vanessa
Conotte, Raphaël
Nonclercq, Denis
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-03-03
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Titanium dioxide (TiO2) nanoparticles (NPs) are produced abundantly and are frequently used as a white pigment in the manufacture of paints, foods, paper, and toothpaste.
Despite the wide ranges of uses, there is a lack of information on the impact of NPs on animal and human health.
In the present study, rats were exposed to different doses of TiO2 nanoparticles and sacrificed, respectively, 4 days, 1 month, and 2 months after treatment.
Dosage of TiO2 in tissues was performed by ICP-AES and revealed an important accumulation of TiO2 in the liver.
The nanoparticles induced morphological and physiological alterations in liver and kidney.
In the liver, these alterations mainly affect the hepatocytes located around the centrilobular veins.
These cells were the site of an oxidative stress evidenced by immunocytochemical detection of 4-hydroxynonenal (4-HNE).
Kupffer cells are also the site of an important oxidative stress following the massive internalization of TiO2 nanoparticles.
Enzymatic markers of liver and kidney functions (such as AST and uric acid) are also disrupted only in animals exposed to highest doses.
The metabonomic approach allowed us to detect modifications in urine samples already detectable after 4 days in animals treated at the lowest dose.
This metabonomic pattern testifies an oxidative stress as well as renal and hepatic alterations.
American Psychological Association (APA)
Valentini, Xavier& Rugira, Pascaline& Frau, Annica& Tagliatti, Vanessa& Conotte, Raphaël& Laurent, Sophie…[et al.]. 2019. Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1192250
Modern Language Association (MLA)
Valentini, Xavier…[et al.]. Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study. Journal of Toxicology No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1192250
American Medical Association (AMA)
Valentini, Xavier& Rugira, Pascaline& Frau, Annica& Tagliatti, Vanessa& Conotte, Raphaël& Laurent, Sophie…[et al.]. Hepatic and Renal Toxicity Induced by TiO2 Nanoparticles in Rats: A Morphological and Metabonomic Study. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1192250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192250